遺傳學(xué)概要

內(nèi)容概要

　　本書(shū)保持了前八版的編寫(xiě)特色：注重基礎(chǔ)知識(shí)，概念清晰準(zhǔn)確，探討解決專(zhuān)業(yè)問(wèn)題，師生易學(xué)易教。第九版內(nèi)容拓展到基因組、生物信息、蛋白質(zhì)組及相關(guān)前沿領(lǐng)域。該書(shū)在亞馬遜專(zhuān)業(yè)教材銷(xiāo)售排行榜長(zhǎng)期名列前茅，被許多北美、歐洲高校教學(xué)選用。
　　第九版內(nèi)容主要包括：遺傳學(xué)概況，有絲分裂和減數(shù)分裂，孟德?tīng)栠z傳學(xué)，孟德?tīng)柋嚷?，真核生物染色體圖譜，細(xì)菌和噬菌體的遺傳分析，性別決定和性染色體，染色體突變：染色體數(shù)量和分布，核外遺傳，dna結(jié)構(gòu)與分析，dna復(fù)制與重組，染色體dna的組織，重組dna技術(shù)和基因克隆，遺傳密碼和轉(zhuǎn)錄，翻譯，基因突變和dna修復(fù)，原核生物基因表達(dá)，真核生物基因表達(dá)調(diào)控，模式生物的發(fā)育遺傳學(xué)，癌癥和細(xì)胞周期調(diào)控，基因組學(xué)，蛋白質(zhì)組學(xué)，生物信息學(xué)，基因組動(dòng)力學(xué)：轉(zhuǎn)座子，免疫遺傳學(xué)，真核病毒，基因組分析——基因功能，基因工程的應(yīng)用及生物倫理剖析，數(shù)量遺傳學(xué)和多因子性狀，行為遺傳學(xué)，群體遺傳學(xué)，進(jìn)化遺傳學(xué)，保護(hù)遺傳學(xué)。
　　本書(shū)適合生命科學(xué)相關(guān)專(zhuān)業(yè)教學(xué)選用，也可供從業(yè)人員參考使用。

書(shū)籍目錄

part one genes,chromosomes,andheredity
　1 introduction to genetics 1
　2 mitosis and meiosis18
　3 mendelian genetics42
　4 extensions of mendelian genetics70
　5 chromosome mapping in eukaryotes 105
　6 genetic analysis and mapping in bacteria andbacteriophages
143
　7 sex determination and sex chromosomes 173
　8 chromosome mutations: variation in chromosome number and
arrangement198
　9 extranuclear inheritance227
　
part two dna: structure replication, and variation
　10 dna structure and analysis245
　11 dna replication and recombination278
　12 dna organization in chromosomes302
　13 recombinant dna technology and gene cloning322
　
part three gene expression,regulationand development
　14 the genetic code and transcription352
　15 translation and proteins381
　16 gene mutation and dna repair410
　17 regulation of gene expression in prokaryotes435
　18 regulation of gene expression in eukaryotes457
　19 developmental genetics of model organisms484
　20 cancer and regulation of the cell cycle511
　
part four genomics
　21 genomics, bioinformatics, and proteomics531
　22 genome dynamics: transposons, immunogenetics, and eukaryotic
viruses574
　23 genomic analysis——dissection of gene function605
　24 applications and ethics of genetic engineering and
biotechnology633
　
part five genetics of organisms and population
　25 quantitative genetics and multifactorial traits668
　26 genetics and behavior688
　27 population genetics710
　28 evolutionary genetics737
　29 conservation genetics 762
appendix a glossarya-1
appendix b answers to selected problemsa-18
appendix c selected readingsa-57
creditsc-1
index i-1

章節(jié)摘錄

　　Events critical to chromosome distribution during mitosis occur dur-ing anaphase， the shortest stage of mitosis. During this phase， sister chromatids of each chromosome disjoin （separate） from each other——an event described as disjunction——and migrate to opposite ends of the cell. For complete disjunction to occur， each centromeric region must split in two. This splitting signals the initiation of anaphase. Once it occurs， each chromatid is referred to as a daughter chromosome.　　Movement of daughter chromosomes to the opposite poles of the cell is dependent on the centromere-spindle fiber attachment. Recent investigations reveal that chromosome migration results from the ac-tivity of a series of specific molecules called motor proteins found at several locations within the dividing cell. These proteins， described as molecular motors， use the energy generated by the hydrolysis of ATP.Their effect on the activity of microtubules serves ultimately to shorten the spindle fibers， drawing the chromosomes to opposite ends of the cell. The centromeres of each chromosome appear to lead the way during migration， with the chromosome arms trailing behind.Several models have been proposed to account for the shortening of spindle fibers. They share in common the selective removal of tubulin subunits at the ends of the spindle fibers. The removal process is ac-complished by the molecular motor proteins described above.　　The location of the centromere determines the shape of the chro-mosome during separation， as you saw in Figure 2-3. The steps that occur during anaphase are critical in providing each subsequent daughter cell with an identical set Of chromosomes. In human cells，there would now be 46 chromosomes at each pole， one from each orig-inal sister pair. Figure 2-7（e） shows anaphase prior to its completion. 　　……

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