內(nèi)分泌系統(tǒng)

內(nèi)容概要

《內(nèi)分泌系統(tǒng)(第2版)》內(nèi)容簡介：“以器官系統(tǒng)為中心”的醫(yī)學(xué)教學(xué)模式是國際醫(yī)學(xué)教育的趨勢。本系列書是世界著名醫(yī)藥衛(wèi)生出版集團(tuán)愛思唯爾公司出版的一套“以器官系統(tǒng)為中心”的醫(yī)學(xué)基礎(chǔ)課程教材。該套教材第1版出版后受到世界各地許多醫(yī)學(xué)院校的歡迎，并被多家進(jìn)行“以器官系統(tǒng)為中心”教學(xué)的醫(yī)學(xué)院校選定為教材。第2版根據(jù)第1版出版后教師和學(xué)生的反饋意見，結(jié)合醫(yī)學(xué)知識的更新進(jìn)行了全新修訂。在編寫內(nèi)容上，該系列教材強(qiáng)調(diào)基礎(chǔ)與臨床的整合。每一章節(jié)都是圍繞著一個(gè)臨床病例展開，通過對病人問題的呈現(xiàn)以及解決過程引出對相關(guān)知識的探究，從而使與器官系統(tǒng)結(jié)構(gòu)、功能以及疾病相關(guān)的重要的基礎(chǔ)醫(yī)學(xué)知識得到了完善的整合。在版式安排上，圖框中的病例資料與正文中的醫(yī)學(xué)知識完美匹配，一步一步地激起讀者的求知欲望。本冊為《內(nèi)分泌系統(tǒng)》。

作者簡介

編者：（英國）漢森（Joy Hinson） （英國）Peter Raven （英國）Shern Chew

書籍目錄

1 INTRODUCTION 1What is endocrinology？ 2What do hormones do？ 2Types of hormone: their synthesis and secretion 4The transport and metabolism of hormones 7Important concepts in endocrine regulation 8Endocrine disorders 10Endocrine investigations: general principles 122 RECEPTORS AND HORMONE ACTION 15Introduction 16General characteristics of receptors 16Types of hormone receptors 17Cell-membrane receptors 17Hormonal regulation of transcription 23Intracellular receptors 24Disorders of receptor function 263 THE HYPOTHALAMUS AND PITUITARY PART I: THE HYPOTHALAMUS AND POSTERIOR PITUITARY 27Introduction 28Where can I find the hypothalamus and pituitary？ 28Connection between the hypothalamus and pituitary 31Development of the hypothalamus and pituitary 31The hormones of the hypothalamus 31The hormones of the posterior pituitary 32Release of posterior pituitary hormones is part of a neuroendocrine reflex: oxytocin secretion and actions 32Regulation of vasopressin secretion 33Actions of arginine vasopressin 34Disorders of vasopressin secretion and action 35Thirst 36Other hypothalamic hormones 374 THE HYPOTHALAMUS AND PITUITARY PART II: THE ANTERIOR PITUITARY 39Introduction 40Structure of the anterior pituitary 40The hormones of the anterior pituitary 41Regulation of hormone secretion in the anterior pituitary 43Growth hormone and prolactin in blood 46Actions of the anterior pituitary hormones growth:hormone and prolactin 46Disorders of anterior pituitary function:over-secretion 48Disorders of under-secretion of anterior pituitaryhormones 49Tests for hypopituitarism 50Insufficient growth hormone secretion 505 THE ADRENAL GLANDS PART I: THE ADRENAL MEDULLA 53Introduction 54Where to find the adrenal glands 54Blood supply 54Nerve supply 55Embryology of the adrenal gland 55The adrenal medulla 55Disorders of the adrenal medulla: phaeochromocytorna 59Familial phaeochromocytoma 59Pharmacological uses of hormones of the adrenal medulla 606 THE ADRENAL GLANDS PART II: THE ADRENAL CORTEX 61Introduction 62Structure of the adrenal cortex 62Hormones produced by the adrenalcortex 62Regulation of steroid production 66Transport of steroid hormones in blood 68Disorders of adrenal steroids 71Pharmacological use of glucocorticoids 737 THE THYROID GLAND 75Introduction 76Thyroid anatomy 77What is a goitre？ 77Blood supply 77Structure of the thyroid 78Synthesis of thyroid hormones 78Iodine 79Thyroxine and T3: the thyroid hormones in blood 79Control of thyroid function 81Cellular action of thyroid hormones 82Effects of thyroid hormones 82Disorders of thyroid hormone secretion 83Causes of thyroid hyposecretion 85Effects of thyroid hormone insufficiency: myxoedema 858 HORMONAL CONTROL OF REPRODUCTION PART I: MALE REPRODUCTIVE SYSTEM 87Introduction 88Where are the testes？ 88What are the testes？ 89Testicular blood and nerve supply 90Spermatogenesis 91Androgen production 91Hormonal control of testicular function 91Transport of testosterone in blood 93Actions of testosterone 93Hormone-dependent cancer in men 95Disorders of male reproduction 96Therapeutic uses of androgens 97Abuse of anabolic androgenic steroids 97Declining sperm counts 989 HORMONAL CONTROL OF REPRODUCTION PART II: FEMALE REPRODUCTIVE SYSTEM 99Introduction 100Structure of the ovary 100Ovarian hormones 100Transport and metabolism of oestrogen andprogesterone 102Oestrogens 102Androgen secretion by,the ovaries 104Hormonal regulation of ovarian function 105Hormone-dependent cancer in women 105The menstrual cycle 105Disorders of the menstrual cycle 108The endocrinology of pregnancy 11010 HORMONAL CONTROL OF REPRODUCTION PART III: DEVELOPMENT AND FERTILITY 115Introduction 116Gender determination and differentiation 116Hormonal control of sexual differentiation 116Abnormalities of sexual differentiation 117Hormones during development: puberty and menarche 118Disorders of puberty 119Menopause and the climacteric 121Premature ovarian failure 122Symptoms of the menopause 122Hormone replacement therapy 123Alternative therapies 125Hormonal control of fertility: contraception 125Hormonal control of fertility: assisted conception 12611 INSULIN AND THE REGULATION OF PLASMA GLUCOSE 129Introduction 130Glucose in urine 130Insulin and the response to high blood glucoselevels 131Disorders of blood glucose regulation: diabetesmellitus 135Gestational diabetes 143The metabolic syndrome——a growing problem？ 14312 HORMONAL REGULATION OF PLASMA CALCIUM AND CALCIUM METABOLISM 147Introduction 148Serum calcium 148The structure, functions and endocrinology of bone 149Hormones involved in the regulation of serumcalcium 151Parathyroid hormone 151Calcitriol: source and activation of vitamin D 153Effects of other hormones on plasma calcium 156Disorders of hypercalcaemia 156Disorders of hypocalcaemia 157Diseases of bone 158A brief mention of calcitonin 159Regulation of serum phosphate 15913 MISCELLANEOUS HORMONES 161Erythropoietin 162Immune-endocrine interactions: cytokines and eicosanoids 163Age-related changes in hormone secretion 164Melatonin 164Gut hormones 166The hormonal control of appetite: fat is an endocrine tissue 167Multiple organ disorders in endocrinology 168Regulation of blood pressure and volume 169The next 100 years of endocrinology 169Glossary 171Index 173

章節(jié)摘錄

版權(quán)頁：插圖：separate from the catalytic subunits. This physical separa-tion causes activation of the two catalytic subunits whichthen phosphorylate serine and threonine residues onspecific cellular proteins. When the bound cAMP dissoci-ates from the binding sites on the regulatory subunits thekinase reassembles itself and the catalytic activity stops.   Phosphorylation of these cellular proteins, usuallyenzymes, causes either activation or deactivation of theenzyme. This is reversed by the action of cellular phos-phatases, which dephosphorylate the protein, returningthe cellular activity to its basal state. An example of a cel-lular protein which is activated in response to phosphor-ylation by protein kinase A is cholesterol ester hydrolase（a hormone-sensitive lipase）, which acts to liberate cho-lesterol in steroidogenic cells in preparation for steroidbiosynthesis.Receptor desensitization and downregulation:GPKs and beta arrestin 'When a hormone binds to a G-protein coupled recep-tor the receptor is usually quickly de-sensitized andeventually internalized within the cell for subsequentbreakdown or recycling. The first step of this processinvolves two families of intracellular proteins which,like the G-proteins, are able to interact with all membersof this receptor family. These are the beta arrestins andthe G-protein coupled receptor kinases （GPK） （Fig. 2.9）.Hormone binding to a receptor causes interaction of thereceptor with G-proteins as we have seen above. It alsoattracts an enzyme of the GPK family which phosphory-lates the receptor. The phosphorylated receptor has alower binding affinity for the hormone but also attractsbeta arrestin binding, which physically blocks interactionof the receptor with G-proteins and so prevents furthersignalling through second messengers.   The desensitized receptors then move through theplasma membrane to accumulate in clathrin-coatedpits （specialized areas of the cell membrane involved inendocytosis） which become internalized within the cell.

編輯推薦

《內(nèi)分泌系統(tǒng)(第2版)》：The Systems of the Body series has established itself as a valuable resource for allmedical and other health science students following system-based courses. In thissecond edition all the volumes have been updated to take into account feedback fromreaders of the first edition. Each volume continues to present the core knowledge ofbasic science and clinical conditions that medical students need, offering an integratedview of the system unavailable from standard textbooks. IntroductionReceptors and hormone action、The hypothalamus and pituitary part I: the hypothalamus and posteriorpituitary、The hypothalamus and pituitary part II: the anterior pituitary、The adrenal glands part I: the adrenal medulla、The adrenal glands part II: the adrenal cortex、The thyroid gland、Hormonal control of reproduction part I: male reproductive system、Hormonal control of reproduction part II: female reproductive system、Hormonal control of reproduction part III: development and fertility、Insulin and the regulation of plasma glucose、Hormonal regulation of plasma calcium and calcium metabolism、Miscellaneous hormones.

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