梁宋平教授文集

內(nèi)容概要

　　《梁宋平教授文集：蛋白質(zhì)與活性多肽探索》收錄了其關(guān)于“蛋白質(zhì)與活性多肽探索”的研究文集，適合從事相關(guān)研究工作的人員參考閱讀。 　　梁宋平教授長(zhǎng)期從事蛋白質(zhì)與活性多肽的結(jié)構(gòu)與功能研究以及蛋白質(zhì)化學(xué)結(jié)構(gòu)測(cè)定方法學(xué)研究。近年來(lái)，在蜘蛛毒素和蛋白岳組學(xué)研究領(lǐng)域連續(xù)獲得到6項(xiàng)國(guó)家自然科學(xué)基金項(xiàng)目和兩項(xiàng)"863"項(xiàng)目資助。

書籍目錄

第一部分  蛋白質(zhì)化學(xué)與蛋白質(zhì)組學(xué)學(xué)術(shù)論文8-(6-氨基己基)-氨基-5-磷酸腺苷Sepharose 4B親和吸附劑的制備與應(yīng)用大熊貓乳酸脫氫酶同工酶MA的純化與某些性質(zhì)的研究The primary structure of the lactate dehydrogenase isozyme Ma from giant pandaA comparison of the primary structures of lactate dehydrogenase isozymes M4 from giant panda，redpanda．black bear and dogCovalent immobilization of proteins and peptides for solid—phase sequencing using prepacked capiHary columnsSingle．step electroelution of proteins from SDS—polyacrylamide gels and immobilization on diisothiocyanate—glassbeads in prepacked capillary columns for solid—phase microsequencingAssignment of the three disulfide bridges of huwentoxin-I，a neurotoxin from the spider Selenocosmia huwena Chemical carboxy-terminal sequence analysis of peptides using acetyl isothiocyanate世紀(jì)之交的蛋白質(zhì)序列測(cè)定技術(shù)Assignment of the three disulfide bonds of Selenocosmia huwena lectin I from the venom of spider Selenocosmia huwenaIndentification of venom proteins of spider S．huwena on two-dimensional electrophoresis gelby N—terminal microsequencing and mass spectrometric peptide mappingChemical carboxyl．terminal sequence analysis of peptides and proteins using tribenzylsilyl isothiocyanateAssignment of the disulfide bonds of huwentoxin—II by Edman degradation sequencing and stepwisethiol modificationC-terminal sequence analysis of peptides using triphenylgermanyl isothiocyanate De nolo sequencing of tryptic peptides sulfonated by 4-sulfophenyl isothiocyanate forunambiguous protein identification using post-source decay matrix．．a(chǎn)ssisted laser desorption／ionization mass spectrometry Proteome comparative analysis of gynogenetic haploid and diploid embryos of goldfish(Carassius auratus) Proteomic analysis of mouse liver plasma membrane：use of differential extraction toenrich hydrophobic membrane proteinsIntegration of a two—phase partition method into proteomics research on rat liver plasma membrane proteins第二部分  蜘蛛活性多肽研究學(xué)術(shù)論文Properties and amino acid sequence of huwentoxin-I，a neurotoxin purified from the venom of the Chinese birdspider Selenocosmia huwena虎紋捕鳥(niǎo)蛛毒的生物學(xué)活性鑒定蜘蛛肽類神經(jīng)毒素研究進(jìn)展A lectin—like peptide isolated from the venom of the Chinese bird spider Selenocosmia huwenaProton nuclear magnetic resonance studies on huwentoxin—I from the venom of the spider Selenocosmia huwena：2．ThFee．dimensional structure in solution DEPD：a novel database for differentially expressed proteinsSolid’phase synthesis of huwentoxin—I and its structure and bioactivity analysisOxidative folding of reduced and denatured huwentoxin．IThree—dimensional structure of Selenocosmia huwena lectin—I(SHL．I)from the venom of the spider Selenocosmiahuwena by 2D-NMRPurification and characterization of huwentoxin—II，a neurotoxic peptide from the venom of the Chinesebird spider Selenocosmia huwena我國(guó)南方捕鳥(niǎo)蛛一新種的生物化學(xué)鑒定(蜘蛛目，捕鳥(niǎo)蛛科)The presynaptic activity of huwentoxin—I，a neurotoxin from the venom of the Chinese bird spider Selenocosmia huwenaThe effect of Huwentoxin—I on Ca2+channels in differentiated NG108-15 cells，a patch—clamp studyFunction and solution structure of huwentoxin—IV，a potent neuronal tetrodotoxin(TI'X)一sensitive sodium channel antagonist from Chinese bird spider Selenocosmi huwenaThe structure of spider toxin huwentoxin—11 with unique disulfide linkage：evidence for structuralevolutioncDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena‘Purification and characterization of raventoxin．I and raventoxin—III，two neurotoxic peptides from thevenom of the spider Macrothele raveniStructure—activity relationships of hainantoxin—IV and structure determination of active and inactivesodium channel blockers An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang[=Ornithoctonus huwena(Wang)]Jingzhaotoxin—III，a novel spider toxin inhibiting activation of voltage—gated sodium channel in ratcardiac myocytesAntinociceptive effects of intrathecally administered huwentoxin—I，a selective N—type calcium channelblocker．in the formalin test in conscious ratsJingzhaotoxin-I，a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivationFunction and solution structure of Huwentoxin—X，a specific blocker of N-type calcium channels．from theChinese bird spider Ornithoctonus huwenaSolution structure and functional characterization of Jingzhaotoxin—XI：A novel gating modifier ofboth potassium and sodium channelsDiscovery of a distinct superfamily of Kunitz—type toxin(KTI")from TarantulasProteome and peptidome profiling of spider venoms第三部分  其他散文與短文寄語(yǔ)即將畢業(yè)的同學(xué)們從倫敦到諾丁漢——訪英隨筆之一阿希武德教授——訪英隨筆之二校園綠地與RAMP——訪英隨筆之三諾丁漢大學(xué)生命科學(xué)系——訪英隨筆之四從數(shù)字看諾丁漢大學(xué)——訪英隨筆之五電子郵件(E—Mail)與環(huán)球信息網(wǎng)(WWW)——訪英隨筆之六神經(jīng)生物學(xué)研究室——訪英隨筆之七揭開(kāi)生命科學(xué)的奧秘心中的銘記——緬懷恩師張龍翔教授開(kāi)學(xué)感賦——與九七級(jí)研究生共勉《生命科學(xué)研究》發(fā)刊詞登攀橋赤子亭記《生命科學(xué)院開(kāi)發(fā)應(yīng)用科研成果匯編》前言關(guān)于學(xué)位論文實(shí)驗(yàn)——與新入學(xué)生物化學(xué)研究生的開(kāi)學(xué)筆談《生物化學(xué)與分子生物學(xué)實(shí)驗(yàn)教程》前言生命科學(xué)對(duì)教育科學(xué)的啟示——2005年在湖南師范大學(xué)研究生“麓山論壇”上的講座蛛海拾貝——在第六屆全國(guó)生物毒素研討會(huì)上所作學(xué)術(shù)報(bào)告的結(jié)束語(yǔ)與2006級(jí)生命科學(xué)學(xué)院研究生共勉致敬愛(ài)的謝錦云老師在2008研究室工作會(huì)議上的結(jié)語(yǔ)一位美國(guó)教授的中國(guó)情結(jié)——記波士頓大學(xué)教授，湖南師范大學(xué)名譽(yù)教授R．A．Lauursen附錄后記

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