生物化學(xué)系統(tǒng)的計(jì)算分析

內(nèi)容概要

This book teaches biochemists and molecular biologists in a hands-on fashion the use of modern computational methods for the analysis of complex biomedical systems; a modest mathemati-cal background will suffice. The book begins with representations of biochemical systems, provides guidelines for setting up models,discusses in detail mathematical and computational methods of pa-rameter estimation and model analysis, and ultimately connects to the modern literature with four detailed case studies. Every step is illustrated with examples and exercises, and is explored with the ac-companying software, PLAS. A dedicated Web site featuring color illustrations, further exercises, research news, as well as resources and links also accompanies this book.

書籍目錄

PrejaceIntroduction1 Graphical Representation of Biochemical Systems2 Models of Biochemical Systems3 From Maps to Equations4 Computer Simulation6 Analytical Steady State Evaluation7 Sensitivity Analysis8 Case Study 1-Anaerobic Fermentation Pathway in Sacchammyces cerevisiae9 Case Study 2-Diagnosis and Refinement of a Model of the Tricarboxylic Acid Cycle in Dictyostelium discoideum10 Case Study 3-A Sequence of Models Describing Purlne Metabolism11 Case Study 4-Algebraic Analysis of the Initial Steps of the Glycolytic-Glycogenoly tic Pathway in Per fused Rat Liver12 Epilogue - Canonical Modeling Beyond BiochemistryAppendixHints and Partial SolutionsReferencesAuthor IndexSubject Index

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