基因與信號

內(nèi)容概要

我國的生命科學(xué)與生物技術(shù)和美國、日本等發(fā)達國家相比還有較大差距，存在生命科學(xué)基礎(chǔ)理論研究不夠深入扎實、學(xué)術(shù)創(chuàng)新能力不強、擁有自主知識產(chǎn)權(quán)的生物技術(shù)產(chǎn)品種類少、產(chǎn)量低、生物技術(shù)產(chǎn)業(yè)規(guī)模小、相關(guān)配套產(chǎn)業(yè)社會化程度低等問題。為了高等院校師生和廣大科技人員借鑒和學(xué)習(xí)發(fā)達國家生命科學(xué)與技術(shù)的先進理論和技術(shù)，提高我國在生物經(jīng)濟方面的競爭力，我們精選了一批國外優(yōu)秀生命科學(xué)與生物技術(shù)著作，組織專家進行了評閱和審核，希望能對高等院校師生和廣大科技人員有所幫助，同時對我國生命科學(xué)和生物技術(shù)產(chǎn)業(yè)趕超世界先進水平起到一定的推動作用。

書籍目錄

PrefaceForewordIntroductionCHAPTER 1 Lessons from Bacteria  RNA POLYMERASE  REGULATED RECRUITMENT:THE/ac GENES    Protein-DNA Interactions    Detecting Physiological Signals    promoter Recognition and Transcription by RNA Polymerase    Switching the Genes On:Activation by CAP      Cooperative Binding of Proteins to DNA      Cooperative Binding and Gene Activation by CAP    Repression by Lac Repressor    Interim Summary and Extension  MORE REGULATED RECRUITMENT:THE BACTERIOPHAGE     The Switch    Establishing Lysogeny    Analogies with lac      promoters       Protein-DNA interactions      Repression      Activation      Detecting Physiological Signals    Making an Efficient Switch      Cooperative Binding of  Repressor to DNA      Autogenous Control by Repressor  PANEL:Antitermination:N and Q    Interim Summary and Extensions      Activation :A Closer Look      DNA binding:A Closer Look      Synergy  POLYMERASE ACTIVATION:glnA AND RELATED GENES    Promoter Recognition by  containing Ploymerase    DNA Binding by NtrC    Detecing the Physiological Signal    Activation by NtrC    Other Activatjors of Polymerase    Interim Summary  PANEL:Phage T4 Late Genes  PROMOTER ACTIVATION:merT AND RELATED GENES    Promoter Recognition    Detection the Physiological and Activation    Interim Summary  GENERAL SUMMARY  PANEL:more on Repression in Bacteria  FOOTNOTES  BIBLIOGRAPHYCHAPTER 2 Yeast:A single-celled Eukaryote……CHAPTER 3 Some Note on Higher EukaryotesCHAPTER 4 Enyme Specificity and RegulationAfterwordAppendicesAppendix1:More on CooperativityApperdix2:Topogenic SepuencesAppendix3:All-or-none Effects and Levels of Gene ExpressionIndex

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