醫(yī)學免疫學

內(nèi)容概要

Essential Medical Immunology is written for medical students in the People's Republic of China　and is adapted largely from Immunology (Seventh Edition) by David Male, Jonathan Brostoff, David B　Roth and Ivan Roit, with the permission of Mosby Elsevier Publishers. Information from other sources,including research articles, has also been included.     Immunology is an experimental biomedical science concerned with the study of the structure and　function of the immune system in all life-forms, while medical immunology emphasizes on the human　system and the diseases associated with it. Starting from the pioneering observations of people like　Edward Jenner, who in 1798 performed the first vaccination, or Frank Widal who, in 1896, developed　the first serological test, immunology has grown enormously to become an important, complex discipline　that has permeated into many other fields of biology, including such diverse areas as neuroscience and　biotechnology.     The book attempts to provide a brief account of immunology to medical students and is divided　broadly into  ' Basic Immunology and Clinical Immunology'. Although the aim is to keep the text simple　and concise, depth has been given to some areas to provide a more comprehensive understanding for the　more enthusiastic students. We hope students will find the book both informative and user-friendly.     We are indebted to Associate Profess~6r Yang Gao, Ms. Xianqian Kong and Ms. Peggy Fung for their　secretarial assistance.

書籍目錄

Section I  Basic Immunology　Chapter 1  Overview of the Immune System   INNATE IMMUNITY       Physical and Chemical Barriers       Phagocytic Cells       Auxiliary Cells       Soluble Mediators       Complement Proteins       Toll-like Receptors   ADAPTIVE IMMUNITY       B and T Cells       Cytokines       Specific Immune Responses       Three Phases of Immune Responses       Crosstalk between Innate and Adaptive Immunity　　IMMUNOPATHOLOGY    　inflammation and Tissue Injury　    Allergen-induced Immunopathology　    Autoantigen-induced Immunopathology　　IMMUNOLOGICAL APPLICATIONS    Vaccination　　Immunotherapys and immunoassays　Chapter 2  Cells, Organs and Tissues of the Immune System   IMMUNE CELLS       Innate Immune Cells       Adaptive Immune Cells   IMMUNE CELL SURFACE RECEPTORS FOR ANTIGENS       Pattern-recognition Receptors on Innate Immune Cells       B Cell Receptor on B Cells    T Cell Receptor on T Cells    MHC Molecules　　IMMUNE ORGANS AND TISSUES　　Primary Lymphoid Organs-Bone Marrow and Thymus　　Secondary Lymphoid Organs and Tissues-Spleen, Lymph Nodes　Chapter 3  Soluble Mediators of the Immune System    ANTIBODIES        Structure of lmmunoglobulins       Bifunctional Activities of lmmunoglobulins        A Vast Repertoire of Antigen-binding Sites         Somatic Hypermutation and Affinity Maturation     COMPLEMENT         Complement Activation Pathways       Complement-mediated Inflammatory Reaction    CYTOKINESChapter 4  The Innate Immune Response    COMPONENTS OF INNATE IMMUNITY       Physical and Chemical Barriers        Phagocytic Cells, NK cells, Blood Proteins and Cytokines　and MALT　　RECOGNITION OF INNATE IMMUNITY    　Pattern Recognition Receptors and Pathogen-associated Molecular Patterns ..　    NK Cells Recognition via Their Inhibitory Receptors and Activating Receptors　　RESPONSE MODELS OF INNATE IMMUNITY        Cytotoxicity to Target Cells        Killing Microbes and Inflammation　Chapter 5  The Adaptive Immune Response    ANTIGEN PRESENTATION        Types of APCs    Antigen Processing    Exogenous Peptides Presented by MHC Class II and Endogenous Peptides Presented by MHC Class    Co-stimulatory Molecules for T Cell Activation    Immunological Synapse    Antigen Presentation and the Course of an Immune Response  　ACTIVATION OF T AND B LYMPHOCYTES　B Ceils Responses to TI or TD Antigens　Signal Transduction in T and B Cell Activations　The Interaction between B Cells and TH Cells  :　Proliferations and Differentiations of Activated T and B Cells……

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