細(xì)胞力學(xué)進(jìn)展

內(nèi)容概要

《細(xì)胞力學(xué)進(jìn)展》(英文版)從交叉學(xué)科的角度系統(tǒng)地介紹和總結(jié)了細(xì)胞力學(xué)和細(xì)胞物理研究領(lǐng)域的前沿課題和最新進(jìn)展。其顯著的特點是用分子力學(xué)和復(fù)雜連續(xù)介質(zhì)力學(xué)的方法研究和計算細(xì)胞的演變和分化；將定量的數(shù)學(xué)力學(xué)分析方法與實驗手段相結(jié)合來探討細(xì)胞的生物物理特性。
《細(xì)胞力學(xué)進(jìn)展》(英文版)適合作為從事分子生物學(xué)、生物工程和力學(xué)、軟物質(zhì)力學(xué)和物理、計算力學(xué)，以及生物化學(xué)和醫(yī)學(xué)的科研人員和研究生的參考書。
《細(xì)胞力學(xué)進(jìn)展》(英文版)的主編是美國加州大學(xué)伯克利分校的李少凡教授和南非科學(xué)院院士、開普半島科技大學(xué)的孫博華教授。

書籍目錄

Chapter 1  Modeling and Simulations of the Dynamics of Growing Cell
Clusters
  1.1  Introduction
  1.2  Single cell geometry and kinematics
    1.2.1  The continuum model
    1.2.2  The numerical model for the cell geometry
  1.3  Single cell equilibrium and material model
    1.3.1  Cell equilibrium
    1.3.2  The material model
    1.3.3  Determination of material constants
  1.4  Modeling cell interactions
    1.4.1  Cell-to-cell contact
    1.4.2  Cell-to-cell adhesion
    1.4.3  Cell-to-cell interaction test
  1.5  Modeling the cell life cycle
  1.6  Details of the numerical implementation
    1.6.1  The finite element model
    1.6.2  Contact/adhesion interface detection
    1.6.3  Time integration
    1.6.4  Parallelization
  1.7  Numerical results
  1.8  Summary and conclusions
  References
Chapter 2  Multiscale Biomechanical Modeling of Stem
Cell-Extracellular Matrix Interactions
  2.1  Introduction
  2.2  Cell and ECM modeling
    2.2.1  Basic hypothesis and assumptions
    2.2.2  Hyperelastic model
    2.2.3  Liquid crystal model
    2.3  Contact and adhesion models for cell-substrate
interactions
    2.3.1  The adhesive body force with continuum mechanics contact
    2.3.2  The cohesive contact model
  2.4  Meshfree Galerkin formulation and the computational
algorithm
  2.5  Numerical simulations
    2.5.1  Validation of the material rhodels
    2.5.2  Cell response in four different stiffness substrates
    2.5.3  Cell response to a stiffness-varying substrate
    2.5.4  Comparison of two different contact algorithms
    2.5.5  Three-dimensional simulation of cell spreading
  2.6  Discussion and conclusions
  References
Chapter 3  Modeling of Proteins and Their Interactions with Solvent
  3.1  Introduction
  3.2  Classical molecular dynamics
    3.2.1  Coarse-grained model
    3.2.2  High performance computing
  3.3  Principal component analysis
    3.3.1  Three oscillators system analysis with PCA
    3.3.2  Quasi-harmonic analysis
    3.3.3  Equilibrium conformational analysis
  3.4  Methods and procedures
    3.4.1  Framework
    3.4.2  Overlap coefficients
    3.4.3  Correlation analysis
    3.4.4  PCA with MD simulation
    3.4.5  Kabsch algorithm
    3.4.6  Positional correlation matrix
    3.4.7  Cluster analysis
  3.5  MD simulation with T4 lysozyme
    3.5.1  Equilibration measures
    3.5.2  Fluctuation analysis
    3.5.3  Mode selection and evaluation
    3.5.4  Eigenvalue analysis
    3.5.5  Overlap evaluation
    3.5.6  Identification of slow conformational flexibility
    3.5.7  Correlation analysis of T4 lysozyme
  3.6  Hemoglobin and sickle cell anemia
    3.6.1  Molecular dynamic simulation with NAMD
    3.6.2  Conformational change analysis
    3.6.3  PCA analysis
    3.6.4  Correlation analysis with HbS interaction
  3.7  Conclusion
  References
Chapter 4  Structural， Mechanical and Functional Properties of
Intermediate Filaments from the Atomistic to the Cellular Scales
  4.1  Introduction
    4.1.1  Hierarchical structure of vimentin intermediate
filaments
    4.1.2  The structural and physiological character of keratin
  4.2  Connecting filaments to cells level function and pathology
    4.2.1  Bending and stretching properties of IFs in cells
    4.2.2  IFs responding differently to tensile and shear stresses
    4.2.3  Mechanotransduction through the intermediate filament
network
  4.3  Experimental mechanics
    4.3.1  Single filament mechanics
    4.3.2  Rheology of IF networks in vitro
    4.3.3  IF networks rheology in cells
  4.4  Case studies
    4.4.1  Single vimentin filament mechanics
    4.4.2  Network mechanics
    4.4.3  The mechanical role of intermediate filament in cellular
system
  4.5  Conclusion
  References
Chapter 5  Cytoskeletal Mechanics and Rheology
  5.1  Introduction
  5.2  Modelling semiflexible filament dynamics
  5.3  Experimental measurements
    5.3.1  Glass microneedles
    5.3.2  Cell poking
    5.3.3  Atomic force microscopy
    5.3.4  Micropipette aspiration
    5.3.5  Microplates
    5.3.6  Parallel-plate flow chambers
    5.3.7  Optical tweezers
    5.3.8  Magnetic traps
  5.4  Computational models
  5.5  Conclusion
  References
Chapter 6  On the Application of Multiphasic Theories to the
Problem of Cell-substrate Mechanical Interactions
  6.1  Introduction
  6.2  The physics of contractile fibroblasts and their
interactions with an elastic substrate
    6.2.1  Cell spreading, contractility and substrate elasticity
    6.2.2  Molecular mechanisms of cell contractility
  6.3  Multiphasic mixture theory and cell contractility
    6.3.1  The cytoplasm as a quadriphasic medium
    6.3.2  Mass transport and mass exchange within the cell
    6.3.3  Contractility and force balance
    6.3.4  Model's prediction for simple cases
  6.4  Interaction between contractile cells and compliant
substrates
    6.4.1  Two-dimensional plane stress formulation
    6.4.2  Numerical strategy: XFEM-level methods
    6.4.3  Analysis of mechanical interactions between a
contractile cell and an elastic substrate
  6.5  Summary and conclusion
    6.5.1  Summary
    6.5.2  Limitations of the multiphasic approach
    6.5.3  Concluding remark
  References
Chapter 7  Effect of Substrate Rigidity on the Growth of Nascent
Adhesion Sites
  7.1  Introduction
  7.2  Model
  7.3  Results and Discussion
  7.4  Conclusion
  References
Chapter 8  Opto-Hydrodynamic Trapping for Multiaxial Single-Cell
Biomechanics
  8.1  Introduction
  8.2  Optical-hydrodynamic trapping.
    8.2.1  Optical physics and microfluidics
    8.2.2  Theoretical stress analysis
    8.2.3  Experimental and computational flow validation
    8.2.4  Applied stresses and strain response
    8.2.5  Multiaxial single-cell biomechanics
  8.3  Discussion
  References
Chapter 9  Application of Nonlocal Shell Models to Microtubule
Buckling in Living Cells
  9.1  Introduction
  9.2  Nonlocal shell theories
    9.2.1  Constitutive relations
    9.2.2  Shear deformable shell model
    9.2.3  Thin shell model
  9.3  Bending buckling analysis
  9.4  Numerical results and discussion
  9.5  Conclusions
Appendix A
Appendix B
Appendix C
Appendix D
References

章節(jié)摘錄

版權(quán)頁：插圖：In this method.the fluid flow through a chamber 8urface coated with a cellmonolayer iS used to study response of cells to fluid flow；a cellular probe iSused to measure this response.Several cell types such as vascular endothe-lial cells and osteocytes are physiologically exposed to fluid flow and shearstress.Cells sense these external forces and react accordingly；this process iscrucial for many regulatory processes.For example，endothelial surface layerhas multifaceted physiological functions and behaves as a transport barrier，as a porous hydrodynamic interface in the motion of red and white cells inmicrovessels，and as a mechanotransducer of fluid shearing stresses to theactin cortical cytoskeleton of the endothelial cell.Endothelial cells adoptan elongated shape in the flow direction if they are subjected to a shear flow.A similar situation exists for osteocytes in bone where mechanosensing con-trols bone repair and adaptive restructuring processes.It iS believed thatstrain.derived flow of interstitial fluid through lacuno-canalicular porositymechanically activates the osteocytes.There are three candidates stimulat-ing cells：wall shear stress.streaming potentials.and chemotransport.Controlling the wall shear stress and measuring its effect on fluid transport.bone cell nitric oxide，and prostaglandin production can be used to study thenature of the flow-derived cell stimuli.Fluid shear stress rate iS also animportant parameter for bone cell activation.

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