生物反應工程原理

內容概要

　　本書從2003年開始在世界范圍內（主要是歐美）被用作課程教材，足以證明其影響力。這是第3版，在以前版本的基礎上進行了大幅修改。本書的核心理念在于：設計生物過程首先要基于對生物系統(tǒng)的模擬，因此，需要引入生物科學里數(shù)學、定量的方法，以期和工程科學完美結合，以指導最佳生物過程的設計，相對于國內大多數(shù)生物反應工程教材，本書更注重基礎、注重數(shù)學方法。這是特別值得借鑒的。
　　在基礎科學部分，本書設計第2、3、4、5章，分別從生物分子、物料守恒、生物反應熱力學和生化反應系統(tǒng)四方面介紹生物過程的科學實質、
　　第6、7、8章，結合前面四章內容，系統(tǒng)總結了酶、細胞、細胞群落三個生物反應過程。側重于用數(shù)學方法描述酶催化、細胞（群落）轉化過程，特別重視基礎科學和工程科學的結合。
　　第9、10、11章介紹生物反應中的工程問題，主要包括發(fā)酵過程的沒計、氣液傳質以及生物過程放大
　　本書理念先進，層次清楚，基礎和工程結合緊密，特別值得引入國內教育領域。

作者簡介

作者：(丹麥)維拉林(John Villadsen) Jens Nielsen Gunnar Liden

書籍目錄

1 What Is This Book About？
　1.1 Note on Nomenclature
2 Chemicals from Metabolic Pathways
　2.1 The Bioreflnery
　2.1.1 Ethanol Production
　2.1.2 Producfion of P1atform Chemicals in the Biorefinery
　2.2 The Chemistry of Metabolic Pathways
　2.2.1 The Currencies Of Gibbs Free Energy and of Reducing
Power
　2.2.2 Glycolysis
　2.2.3 Fermentative Metabolism：Oxidation of NADH in Anaerobic
Processes
　2.2.4 The TCA Cycle：Provider of Building Blocks and
NADH／FADH，
　2.2.5 Production of ATP bv 0xidative Phosphorylation
　2.2.6 The Pentose Phosphate Pathway：A Multipurpose Metabolic
Network
　2.2.7 Summary of the Primary Metabolism of Glucose
　2.3 Examples of Industrial Production 0f Chemicals by
Bioprocesses
　2.3.1 Amino Acids
　2.3.2 Antibiotics
　2.3.3 Secreted Proteins
　2.4 Design of Biotech Processes：Criteria for Commercial
Success
　2.4.1 Strain Design and Selection
　2.4.2 Criteria for Design and Optimization of a Fermentation
Process
　2.4.3 Strain Improvement
　2.5 T11e Prospects of the Biorefmery
　Problems
　References
3 Elemental and Redox Balances
　3.1 The Continuous.Stirred Tank Reactor
　3.1.1 Mass Balances for all Ideal.SteadY-State Corninuous Tank
Reactor
　3.2 Yield Coefncients
　3.3 Black BOX Stoichiometries
　3.4 Degree of Reduction Balances
　3.4.1 Consistency Test of Experimental Data
　3.4.2 Redox Balances Used in the Design of Bioremediation
Processes
　3.5 Systematic Analysis of Black BOX Stoichiometries
　3.6 Identification of Gross Measurement Errors
　Problems
　References
4 Thermodynamics OfBioreactions
　4.1 Chemical Equilibrium and Thermodynamic State Functions
　4.1.1 Changes in Free Energy and Enthalpy
　4.1.2 Free Energy Changes in Bioreactions
　4.1.3 Combustion：A Change in Reference State
　4.2 Heat ofReaction
　4.2.1 Nonequilibrium Thermodynamics
　4.2.2 Free Energy Reclaimed by Oxidation in the E1ec on Transfer
Chajn
　4.2.3 Production of ATP Mediated by F0一F1 ATP Synthase
　Problems
　References
5 Biochemical Reaction Networks
　5.1 Basic Concepts
　5.1.1 Metabolic Network with Diverging Branches
　5.1.2 A FormalMatrix .Based Description of Metabolic
Networks
　5.2 Growth Energetics
　5.2.1 Consumption of ATP for Cellular Maintenance
　5.2.2 Energetics ofAnaerobic Processes
　5.2.3 Energetics ofAerobic Processes
　……
6 Enzyme Kinetics and Metabolic Control Analysis
7 Growth Kinetics ofCell Cultures
8 Population Balance Equations
9 Design of Fermentation Processes
10 Gas-Liquid Mass Transfer
11 Scale-Up ofBioprocesses
Index

章節(jié)摘錄

版權頁：插圖：Matrix algebra is necessary to understand, even on a superficial level, theconcepts discussed in papers on Systems Biology, and we introduce matrix-basedMetabolic Flux Analysis in Chap. 5. But the subject is introduced slowly aftersimple networks have been studied by methods that require very little beyond basicalgebra. Similarly, at the end of Chap. 3, methods that are necessary to evaluate thequality of experitnental data are discussed, but only after many examples whereelemental and redox balances are used to analyze steady-state rate data and toderive the stoichiometry of bioreactions. When in Chap. 6 reactions catalyzed byimmobilized enzymes are treated, one must apply some basic concepts fromtransport phenomena. Diffusion into the pellets is treated with the help of detailedexamples. The objective is to give the reader an understanding of the topic which ison the par with that given in standard texts on Chemical Reaction Engineering.   The book has more than 100 examples and notes. The Examples will help thereader to better understand the text while topics which extend the text, sometimesby pointing to applications in different areas, are treated in Notes. The teaching of the examples is further extended into the Problem sections of each chapter. Some of the examples and problems are simple illustrations of the text, while others aredetailed quantitative studies relevant for building up a further understanding of bio-reactions, both for use in scientific studies and for design of equipment. The designexamples often refer to the collaboration of the authors with major bio-techcompanies - suitably reformulated if necessary. Hopefully these design examples demonstrate that Bio-reaction Engineering, by combining core subjects from Chemical Engineering and the Bio-Sciences, contributes to secure bioprocesses aprominent place in the process industry.

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《生物反應工程原理(原著第3版)(英文版)》是國外化學經典教材系列(影印版)。

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