高等有機化學

內(nèi)容概要

　　自從1977年面世以來，《高等有機化學》作為學科首選教材的地位一直沒有動搖過，廣泛地覆蓋了有機化合物的結(jié)構(gòu)、反應活性及合成。她的第五版相對2001年出版的第四版進行了大幅度的修訂，更新了學科發(fā)展的相關(guān)資料，內(nèi)容組織更加清晰明朗，特別是計算化學部分。通過控制反應而得到特定的合成是有機合成的全部目標。PartB在不同反應類型的基礎上詳盡地描述了最常見的和最有用的合成反應。每章后附有習題精選及解答習題的推薦參考文獻?！　”緯晒┯袡C化學、藥物化學和生物化學等專業(yè)的高年級本科生、研究生以及相關(guān)領域的科研人員參考。

作者簡介

作者：(美國)卡雷 (Carey.F.A.) (美國)松德貝里 (Sundberg.R.J.)

書籍目錄

PrefaceAcknowledgment and Personal StatementIntroductionChapter 1.  Alkylation of Enolates and Other Carbon Nucleophiles　Introduction　1.1. Generation and Properties of Enolates and Other Stabilized Carbanions　　1.1.1. Generation of Enolates by Deprotonation　　1.1.2. Regioselectivity and Stereoselectivity in Enolate Formation from Ketones and Esters　　1.1.3. Other Means of Generating Enolates　　1.1.4. Solvent Effects on Enolate Structure and Reactivity 1.2. Alkylation of Enolates　　1.2.1. Alkylation of Highly Stabilized Enolates　　1.2.2. Alkylation of Ketone Enolates　　1.2.3. Alkylation of Aldehydes, Esters, Carboxylic Acids, Amides, and Nitriles　　1.2.4. Generation and Alkylation of Dianions　　1.2.5. Intramolecular Alkylation of Enolates　　1.2.6. Control of Enantioselectivity in Alkylation Reac:ions  1.3. The Nitrogen Analogs of Enols and Enolates: Enamines and Imine Anions  General References  ProblemsChapter 2.  Reactions of Carbon Nucleophiles with Carbonyl Compounds  Introduction  2.1. Aldol Addition and Condensation Reactions　　2.1.1. The General Mechanism　　2.1.2. Control of Regio- and Stereoselectivity of Aldol Reactions of Aldehydes and Ketones 　 2.1.3. Aldol Addition Reactions of Enolates of Esters and Other Carbonyl Derivatives　　2.1.4. The Mukaiyama Aldol Reaction　　2.1.5. Control of Facial Selectivity in Aldol and Mukaiyama Aldol Reactions　　2.1.6. Intramolecular Aldol Reactions and the Robinson Annulation  2.2. Addition Reactions of Imines and Iminium Ions　　2.2.1. The Mannich Reaction　　2.2.2. Additions to N-Acyl Iminium Ions　　2.2.3. Amine-Catalyzed Condensation Reactions  2.3. Acylation of Carbon Nucleophiles　　2.3.1. Claisen and Dieckmann Condensation Reactions　　2.3.2. Acylation of Enolates and Other Carbon Nucleophiles  2.4. Olefination Reactions of Stabilized Carbon Nucleophiles　　2.4.1. The Wittig and Related Reactions of Phosphorus-Stabilized Carbon Nucleophiles 　 2.4.2. Reactions of a-Trimethyisilylcarbanions with Carbonyl Compounds　　2.4.3. The Julia Olefination Reaction  2.5. Reactions Proceeding by Addition-Cyclization　　2.5.1. Sulfur Yiides and Related Nucleophiles　　2.5.2. Nucleophilic Addition-Cyclization of ot-Haloesters  2.6. Conjugate Addition by Carbon Nucleophiles　　2.6.1. Conjugate Addition of Enolates　　2.6.2. Conjugate Addition with Tandem Alkylation　　2.6.3. Conjugate Addition by Enolate Equivalents　　2.6.4. Control of Facial Selectivity in Conjugate Addition Reactions　　2.6.5. Conjugate Addition of Organometallic Reagents　　2.6.6. Conjugate Addition of Cyanide Ion   General References   ProblemsChapter 3.  Functional Group Interconversion by Substitution, Including Protection and Deprotection  Introduction  3.1. Conversion of Alcohols to Alkylating Agents　  3.1.1. Sulfonate Esters　  3.1.2. Halides  ……Chapter 4. Electrophilic Additions to Carbon-Carbon Multiple BondsChapter 5. Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Croups, and Other Functional GroupsChapter 6. Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal EliminationsChapter 7. Organometallic Compounds of Group I and II MetalsChapter 8. Reactions Involving Transition MetalsChapter 9. Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silcon, and TinChapter 10. Reactions Involving Carbocations, Carbenes, and Radicals and Reactive IntermediatesChapter 11. Aromatic Substitution ReactionsChapter 12. OxidationsChapter 13. Multistep SynthesesReferencesIndex

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《高等有機化學:反應與合成(第5版)》可供有機化學、藥物化學和生物化學等專業(yè)的高年級本科生、研究生以及相關(guān)領域的科研人員參考。

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