面向醫(yī)學(xué)治療的微納米技術(shù)

內(nèi)容概要

本書討論了正在興起的治療性微米和納米技術(shù)領(lǐng)域。本書所覆蓋的主題包括：基于細(xì)胞的治療技術(shù)，再生醫(yī)學(xué)——細(xì)胞與微米和納米系統(tǒng)整合（融合），MEMS與細(xì)胞和組織的集成；藥物的傳遞-用于血管內(nèi)物靶向傳遞的納米粒子和非血管系統(tǒng)的藥物傳遞系統(tǒng)（植入性的、口服的、吸入性的）；用于生物界面的分子表面工程，生物分子圖案化和細(xì)胞圖案化。    本書可供從事納米科技、材料科學(xué)、生物化學(xué)和醫(yī)學(xué)的科研人員，高等院校研究生、教學(xué)人員參考。

作者簡(jiǎn)介

作者：(加拿大)德塞(Desai T．) (美國(guó))巴蒂亞( Bhatia S)

書籍目錄

List of ContributorsForewordPrefaceI.Cell-based Therapeutics　1.Nano-and Micro-Technology to Spatially and Temporally Control　　Proteins for Neural Regeneration　　Anjana Jain and Ravi V Bellamkonda　　1.1 Introduction　　　1.1.1 Response after Injury in CNS and PNS　　　1.1.2 Nano-and Micro-scale Strategies to Promote Axonal Outgrowth in the CNS and PNS　　1.2 Spatially Controlling Proteins　　　1.2.1 Spatial Control: Permissive Bioactive Hydrogel Scaffolds for Enhanced Regeneration　　　1.2.2 Spatial Control: Chemical vs.Photochemical Crosslinkers for Immobilization of Bioactive Agents　　　1.2.3 Other Hydrogel Scaffolds　　　1.2.4 Spatial Control: Contact.Guidance as a Strategy to Promote Regeneration　　　1.2.5 Spatial Control: Nerve Guide Conduits Provide an Environment for Axonal Regeneration　　　1.2.6 Spatial Control: Cell-scaffold Constructs as a Way of Combining Permissive Substrates with Stimuli for  Regeneration　　1.3 Temporally Controlling the Release of Proteins　　　1.3.1 Temporal Control: Osmotic Pumps Release Protein to Encourage Axonal Outgrowth　　　1.3.2 Temporal Control: Slow Release of Trophic Factors Using Microspheres　　　1.3.3 Temporal Control: Lipid Microtubules for Sustained Release of Stimulatory Trophic Factors　　　1.3.4 Temporal Control: Demand Driven Release of Trophic Factors　　1.4 Conclusion　　　References　　2.3-D Fabrication Technology for Tissue Engineering　　　Alice A.Chen, Valerie Liu Tsang, Dirk Albrecht, and Sangeeta N.Bhatia    2.1 Introduction    2.2 Fabrication of Acellular Constructs　　　2.2.1 Heat-Mediated 3D Fabrication　　　2.2.2 Light-Mediated Fabrication　　　2.2.3 Adhesive-Mediated Fabrication　　　2.2.4 Indirect Fabrication by Molding　　2.3 Fabrication of Cellular Constructs    2.4 Fabrication of Hybrid Cell/Scaffold Constructs　　　2.4.1 Cell-laden Hydrogel Scaffolds by Molding  　　3.3.4 Extensive Neurite Outgrowth and Active Synapse Formation on PuraMatrix　　　3.3.5 Compatible with Bioproduction and Clinical Application　　　3.3.6 Synthetic Origin and Clinical-Grade Quality　　　3.3.7 Tailor-Made PuraMatrix　   3.4 Peptide Surfactants/Detergents Stabilize Membrane Proteins　   3.5 Perspective and Remarks　　　Acknowledgements　　　References　4.At the Interface: Advanced Mierofluidic Assays for Study of Cell Function　　Yoko Kamotani, Dongeun Huh, Nobuyuki Futai, and Shuichi Takayama　　4.1 Introduction　　4.2 Microfabrication  　　　4.2.1 Soft Lithography　　……　5.Multi-phenotypie Cellular Arrays for Biosensing　6.MEMS and NeurosurgeryII.Drug Delivery  7.Vascular Zip Codes and Nanoparticle Targeting　8.Engineering Biocompatible Quantum Dots for Ultrasensitive,Real-Time Biological Imaging and Detection　9.Diagnostic and Therapeutic Applications of Metal Nanoshells　10.Nanoporous Microsystems for Islet Cell Replacement　11.Medical Nanotechnology and Pulmonary Pathology　12.Nanodesigned Pore-Containing Systems for Biosensing and Controlled Drug Release　13.Trandermal Drug Delivery using Low-Frequency Sonophoresis　14.Microdevices for Oral Drug Delivery　15.Nanoporous Implants for Controlled Drug DeliveryIII.Molecular Surface Engineering for the Biological Interface　16.Micro and Nanoscale Smart Polymer Technologies in Biomedicine　17.Supported Lipid Bilayers as Mimics for Cell Surfaces　18.Engineering Cell Adhesion  　19.Cell Biology on a ChipAbout the EditorsIndex

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