化學生物學

內容概要

《生命科學新視野》叢書精選Trends、Current Opinion和Drug Discovery Today等系列出版物中的部分最新論文，以原文稍加中文注解的形式，按專題編輯成冊。本書為其中一冊，共有25篇文章，主要涉及生物催化、生物轉化、人工進化等內容。    本書將主要面向大學高年級學生、教師、研究生以及科研工作者，供其參考和收藏。

書籍目錄

中文摘要化學生物學Enzymatic tools for engineering natural product glycosylationSophie Blanchard and Jon S Thorson天然產物糖基化的工具酶Nucleic acid aptamers and enzymes as sensorsNaveen K Navani and Yingfu Li作為傳感器的核酸適配子和酶Catalytic antibodies and their applicationsCarl Veith Hanson，Yasuhim Nishiyama and Sudhir Paul催化抗體及其應用The evolution of DNA polymerases with novel activitiesAllison A Henry and Floyd E Romesberg新活性DNA聚合酶的人工進化Understanding enzyme action on immobilised substratesPeter J Hatling,Rein V Ulijn and Sabine L Flitsch酶對固定化底物的作用Mining genomes and‘metagenomes’for novel catalystsManuel Ferrer，Francisco Ma rtnez-Abarca and Peter N Golyshin從基因組和“宏基因組”中尋找新型催化劑Ultra-high-throughput screening based on cell-surface display and fluorescence-activated cell sorting for the identification of novel biocatalystsStefan Becker，Hans—Ulrich Schmoldt，Thorsten Michael Adams，Susanne Wilhelm and Harald Kolmar基于細胞表面展示及熒光活化細胞分類的超高通量篩選，尋找新型生物催化劑Improved β-lactam acylases and their use as industrial biocatalystsCharles F Sio and Wim J Quax改良的β-內酰胺?；D移酶及其作為工業(yè)生物催化劑的應用Enzyme catalysed deracemisation and dynamic kinetic resolution reactionsNicholas J Turner酶催化的去消旋化和動態(tài)動力學拆分Peroxide-utilizing biocatalysts：structural and functional diversity of heme-containing enzymesIsamu Matsunaga and Yoshitsugu Shiro利用過氧化物的生物催化劑：含有亞鐵血紅素的酶的結構與功能的多樣性Hydrogenases：active site puzzles and progressFraser A Armstrong氫化酶：活性位點之謎與進展EnantioseIective biocatalysis optimized by directed evolutionKarl-Erich Jaeger and Thorsren Eggert通過定向進化優(yōu)化對映選擇性生物催化劑Evolving haloalkane dehalogenasesDick B Janssen鹵烷烴去鹵化酶的人工進化Harnessing microbial activities for environmental cleanupFrank E Loffier．Elizabeth A EdwardS利用微生物活性進行環(huán)境凈化BioethanolKevin A Gray，Lishan Zhao and Mark Emptage生物乙醇Chemical diversity through biotransformationsMichael Muiller生物轉化帶來的化學多樣性Metabolic engineering of Escherichia coil and Corynebacterium glutamicum for biotechnological production of organic acids and amino acidsvolker F Wendisch，Michaet Bott and Bernhard J Eikmanns生產有機酸和氨基酸的大腸桿菌與谷氨酰胺棒狀桿菌的代謝工程Recent advances in oxygenase-catalyzed biotransformationsVlada B Urlacher and ROIf D Schmid加氧酶催化的生物轉化的最新進展The soil metagenome-a rich resource for the discovery of novel natural productsRolf Daniel土壤宏基因組一發(fā)現新型天然產物的寶庫Biocatalysis in pharmaceutical preparation and alterationBarrie Wilkinson and Brian O Bachmann藥物制備與改造中的生物催化High-throughput screening of biocatalytic activity：applications in drug discoveryR Anand Kumar and Douglas S Clark生物催化活性的高通量篩選：在藥物發(fā)現中的應用High-throughput screens and selections of enzyme-encoding genesAmir Aharoni,Andrew D Griffiths and Dan S Tawfik酶編碼基因的高通量篩選與精選Predicting enzyme function from protein sequenceJeremy Minshull，Jon E Ness，Claes Gustafsson and Sridhar Govindarajan從蛋白質序列預測酶功能Synthesis and modifications of carbohydrates，using biotransformationsAlison M Daines，Beatrice A Maltman and Sabine L Flitsch應用生物轉化進行碳水化合物的合成和修飾Whole organism biocatalysisTakeru Ishige，Kohsuke Honda and Sakayu Shimizu全生物體生物催化

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