生物信息學

內容概要

“精要速覽系列(Instant Notes Series)”是國外教材“Best Seller”榜的上榜教材。該系列結構新穎，視角獨特；重點明確，脈絡分明；圖表簡明清晰；英文自然易懂，被國內多所重點院校選用作為雙語教材。先鋒版是繼“現(xiàn)代生物學精要速覽”之后推出的跨學科的升級版本。    本書是該系列中的《生物信息學》分冊，全書共15章，全面系統(tǒng)地概括了該學科的核心內容和前沿動態(tài)，涉及生物學數(shù)據(jù)的獲得與處理、系統(tǒng)發(fā)生學、芯片數(shù)據(jù)分析、蛋白質組數(shù)據(jù)分析、生物信息學的應用等主要內容。    本書是指導大學生快速掌握生物信息學基礎知識的優(yōu)秀教材，也是輔助教師授課的極佳教學參考書，同時可供生命科學相關專業(yè)的研究生參考。

書籍目錄

AbbreviationsPrefaceSection A-Overview of bioinformatics        A1 The scoe of bioinformatics        A2 Bioinformatics and the Internet        A3 Useful bioinformatics sites on the WWWSection B- Data acquisition        B1 Sequencing DNA,RNA and proteins        B2 Determination of protein structure        B3 Gene and protein expression data        B4 Protein interaction dataSection C-Databases-contents,structure and annotation        C1 File formats        C2 Annotated sequence databases        C3 Genome and organism-specific databases        C4 Miscellaneous databasesSection D-Retrieval of biological data        D1 Data retrieval with Entrez and DBGET/LinkDB        D2 Data retrieval with SRS(sequence retrieval system)Section E-Searching sequence databases by sequence        E1 Sequence similarity searches        E2 Amino acid substitution matrices        E3 Databases searches:FASTA and BLAST        E4 Sequence filters        E5 Iterative database searches and PSI-BLASTSection F-Multiple sequence alignment and family relationships        F1 Multiple sequence alignment and family relationships        F2 Protein families and pattern databases        F3 Protein domain familiesSection G-Phylogenetics        G1 Phylogenetics,cladistics and ontology        G2 Building phylogenetic trees        G3 Evolution of macromolecular sequencesSection H-Sequence annotation        H1 Principles of genome annotation        H2 Annotation tools and resourcesSection I-Structural bioinformatics        I1 Conceptual models of protein structure        I2 The relationship of protein three-dimensional structure to protein function        I3 The evolution of protein structure and function        I4 Obtaining,viewing and analyzing structural data        I5 Structural alignment        I6 Classification of proteins of known three-dimensional structure:CATH and SCOP        I7 Introduction to protein structure prediction        I8 Structure prediction by comparative modeling        I9 Secondary structure prediction        I10 Adnanced protein structure prediction and prediction strategiesSection J-Microarray data analysis        J1 Microarray data:analysis methods        J2 Microarray data:tools and resources        J3 Sequence sampling and SAGESection K-Proteomic data analysis        K1 Analyzing data from 2D-PAGE gels        K2 Analyzing protein mass spectrometry dataSection L-Higher-order systems        L1 Modeling and reconstructing molecular pathways        L2 Protein interaction informatics        L3 Higher-order modelsSection M-Cheminformatics in biology        M1 Conventions for representing molecular pathways        M2 Cheminformatics resourcesSection N-Bioinformatics in the pharmaceutical industry        N1 Bioinformatics and drug discovery        N2 Pharmainformatics resourcesSection O-Basic principles of computing in bioinformatics        O1 Running computer software        O2 Computer operating systems        O3 Software downloading and installation        O4 Database managementFurther readingGlossaryIndex

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